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Metformin hydrochloride (Standard) is an analytical standard for research and analytical applications. It inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, useful for type 2 diabetes studies. It also inhibits liver oxidative stress and inflammation, and regulates autophagy to inhibit renal cell carcinoma growth.
Analytical standard for research and analytical applications.
Inhibits mitochondrial respiratory chain in the liver.
Activates AMPK and enhances insulin sensitivity.
Used in type 2 diabetes research.
Inhibits liver oxidative stress and inflammation.
Regulates autophagy-related proteins.
Inhibits mTOR signaling pathway.
Induces tumor cell autophagy and inhibits renal cell carcinoma growth.
Suitable for HPLC, GC, and MS research.
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PSB-1115 is a selective A2B adenosine receptor antagonist used as a research tool to block A2B-mediated signaling in vitro and in vivo. It is reported to antagonize adenosine-mediated effects in animal models and to inhibit TNBS-induced responses.
Selective A2B adenosine receptor antagonist for research use.
High purity (99.0%) solid suitable for biological assays.
Chemical formula C14H14N4O5S; molecular weight 350.35 g·mol⁻¹.
Soluble in DMSO (100 mg/mL) and water (10 mg/mL) with sonication or warming.
Recommended storage at -20°C; in solution, store at -80°C for long-term stability.
Reported in vivo activity at 0.5 mg/kg (i.p.) in mouse mucociliary clearance studies.
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Phenylbiguanide hydrochloride is the hydrochloride salt of phenylbiguanide, a selective 5-HT3 receptor agonist commonly used in receptor pharmacology and in vitro pharmacological assays. It is supplied as a research-grade reagent with supporting documentation for characterization and safe handling.
Selective 5-HT3 receptor agonist (EC50 ≈ 3.0 μM).
High purity: 99.8% by analytical testing.
Molecular weight: 213.67 g/mol.
CAS number: 55-57-2.
Available in multiple pack sizes, including 25 g.
Provided with datasheet and safety data sheet for handling and storage.
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PSB-1115 is a selective A2B adenosine receptor antagonist supplied for research use to investigate A2B-mediated signaling and physiological responses. It has documented activity in TNBS-induced contraction models and is provided in solid and solution formats for experimental applications.
Selective A2B adenosine receptor antagonist.
Research-use compound for A2B receptor studies.
Purity 99.0%.
Molecular formula C14H14N4O5S; molecular weight 350.35.
CAS number 152529-79-8.
Available in solid 5 mg and solution 10 mM 1 mL in DMSO.
Store at -20°C; protect from light. In solvent: -80°C for 6 months, -20°C for 1 month.
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Metformin, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug. Metformin inhibits the proliferation of a range of cancer cells including prostate, colon, breast, ovarian, and glioma lines. 1115-70-4. MFCD00012582
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Zoniporide hydrochloride hydrate is the hydrochloride hydrate salt of zoniporide, a potent and selective inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1). It inhibits human NHE-1 with an IC50 of 14 nM and shows strong selectivity over other NHE isoforms, making it suitable for in vitro research on NHE-1-mediated pathways. Supplied as a high-purity solid for laboratory research.
Potent NHE-1 inhibitor with an IC50 of 14 nM.
Greater than 150-fold selectivity versus other NHE isoforms.
High purity suitable for analytical and biological assays (purity reported 99.37%).
Molecular weight 374.82 g·mol⁻¹.
Available in small milligram pack sizes for research use.
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